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Hyzaar may also be used for purposes not listed in this medication guide LOSARTAN; HYDROCHLOROTHIAZIDE (loe SAR tan; hye droe klor oh THYE a zide) is a combination of a drug that relaxes blood vessels and a diuretic. Hyzaar; Descriptions. Hyzaar contains a combination of hydrochlorothiazide and Order Glucophage Online Rx Pharma losartan. You should also take care to avoid exposing the medicine to light. 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